Comparative analysis of hematological parameters in Type-2 Diabetes Mellitus patients and Healthy residents of Lahore, Pakistan

Abstract

Background: Type-2 Diabetes Mellitus (T2DM) is a one of the most widespread metabolic disorder which involves blood and cellular level fluctuations. Various studies report the altered hematological parameters in T2DM, but results are conflictive. Therefore, present study was designed to compare the hematological parameters of adult T2DM patients with healthy control residents of Lahore, Pakistan.

Methodology: This comparative cross-sectional study was conducted at the hematology lab of Jinnah Hospital, Lahore, Pakistan. A total of 60 study subjects were enrolled (T2DM=30, Healthy controls=30) who fulfilled the strict inclusion criteria. Blood samples were collected from enrolled participants in sterile EDTA tubes and hematological parameters were noted using the automated hematology analyzer. The medical history of the enrolled participants was collected on the self-administered data collection form.

Results: The results of present study revealed that the mean values of white blood cells (9.92±8.14), lymphocytes (46.76±26.75), and mean corpuscular volume (80.62±9.91) were significantly different in two groups and were found to be high in T2DM group as compared to healthy control group. There were minor changes between hematocrit, mean corpuscular hemoglobin concentration, platelet, platelet distribution width in diabetic patients as compared to healthy control group. The mean values of hemoglobin, red blood cells, platelet, mean platelet volume, mean corpuscular hemoglobin, and neutrophils decreased in T2DM patients as compared to control group.

Conclusion: This study shows statistically significant variations in white blood cells, lymphocyte and mean corpuscular volume in T2DM group as compared to the healthy control group. The results suggest routine hematological parameters evaluation of T2DM patients for effective management of the disease.