Evaluation of Hepato-Renal Protective potential of Aloe Vera Gel and Bitter Melon Seed Powder in Sprague Dawley Rats

Abstract

Background: Worldwide, for the management of numerous diseases Complementary and alternative medicine (CAM) are used. Aloe barbadensis Miller (aloe vera) and Momordica charantia (bitter melon) both are known for their medicinal and therapeutic potential including anti-inflammatory, anti-diabetic, and antibacterial.

Objective: To probe bitter melon seed (BMS) powder and aloe vera gel (AVG) powder effect on liver and kidney functions in diabetic Sprague Dawley Rats.

Methodology. For this purpose, BMS powder and AVG powder were prepared and used in two different concentrations to check its action through efficacy studies in Sprague Dawley Rats during 30 days’ trial. Blood samples were collected fortnightly and assessed for change liver function tests and kidney function tests. All the parameters were analyzed statistically to determine the level of significance.

Results: Results revealed that AVG and BMS powder in combination was very effective in controlling diabetes-related dysfunction of the liver and kidney. The group receiving 50% AVG and 50% BMS powder showed significantly reduce blood urea nitrogen (13.17 mg/dL) and uric acid (6.03 mg/dL) over the period of 30 days, whereas the group treated with and 25% AVG and 75% BMS powder showed improvement in alanine transferase (56.50 U/L), aspartate aminotransferase (48.67 U/L), alkaline phosphatase (170.17 U/L), and creatinine (0.61 mg/dL).

Conclusion: Supplementation of BMS and AVG has no bad effect on the liver and kidney, moreover, it was effective in controlling elevated liver and kidney function parameters.