Effect of Corona Virus on Multi-Organs Diagnostics Biomarkers Among COVID-19 Positive Hospitalized Patients in Pakistan

Abstract

Background: COVID-19 is a pandemic that affects millions of people worldwide Pakistan. The lungs are the organs that are most affected by COVID-19. It can also affect other organs such as heart, liver and kidneys. The biomarker parameters associated with these can fluctuate with the disease, which can lead to organ failure.

Objective: The objective of this study was to assess multiple organ biomarkers in hospitalized COVID-19-positive patients within the Pakistani population and explore their correlation with the severity of the disease.

Results: In this cross-sectional study, 269 blood samples (239 males and 30 females) were collected from COVID-19 positive patients. Serum was separated from all the blood specimens for the determination of chemical analytes such as cardiac biomarker (CK, LDH), liver biomarkers (ALP, ALT, bilirubin and albumin), kidneys biomarkers (urea and creatinine), electrolytes (sodium and potassium) and inflammatory marker such as C[1]reactive protein (CRP) on fully automated Chemistry Analyzer COBAS C501 in the teaching hospital of University of Lahore, Pakistan.

Conclusion: In COVID-19 positive patients the level of LDH, CK and CRP were higher (abnormal) while Albumin, Urea, and Sodium showed decreased levels. These abnormal values were mostly in older patients (61-80) Albumin, creatinine and CRP showed significant p values after statistical analysis using SPSS. Thus, COVID-19 mostly effects Cardiac and Hepatic cells in comparison to other organs