Prevalence of Differential HCV genotypes and their Treatment Regimen

Abstract

Background: Hepatitis C virus (HCV) is a blood-borne virus that can cause chronic hepatitis, a life-threatening liver disease. HCV belongs to the flavivirus family with a single-stranded RNA genome and a 9.6-kb genome. HCV infects both humans and other mammals and can spread through blood or blood products. Hepatitis C virus can infect persons of all ages, but hepatitis C virus found a high incidence rate in adults. The current study was intended to determine the prevalence of differential HCV genotype and their treatment regimen.

Methodology: The present study was carried out in Rehman medical institute (RMI) at the Department of Molecular Diagnostics. The Hepatitis C Virus Genotyping (LINEAR ARRAY) Test was used for HCV Genotyping.

Results: The result showed that genotype 3 of HCV (1-6) was the most prevailing while genotype 1, genotypes 1&3, and genotypes 1&4 are less common. The mix genotyping was recorded in 14 patients in which 07 is genotype 1&3 and 07 patients were recorded as genotype 1&4 while genotype 3 was recorded.

Conclusion: Current study concludes that HCV genotype 3 was highly prevalent in the Peshawar region of Pakistan while genotype 1, and mix genotype 1&3, mix genotype 3&4 is less common and the age group of the majority of the patients was within 36 to 65 year and the treatment of HCV the SOVALDI (Sofosbuvir) was the drug of choice as compared to available medication/treatment regimen n 47 patients.