New Insights into the Role of Coenzyme Q10 in Serum LDLCholesterol Reduction

Abstract

Objective: To explore effect of Coenzyme Q10 (Co Q10) on serum LDL-Cholesterol and compare its hypolipidemic efficacy with the normal control.
Study Design: Randomized control trial.
Place and Duration of Study: The study was conducted from 1st February 2013 to 30th June 2013 at the department of chemical pathology, Army Medical College and National Institute of Health Sciences (NIH) Islamabad.
Materials and Methods: Eighteen rabbits were divided into three groups of six rabbits each. Base line lipid profile was estimated for serum LDL cholesterol in mmol/L. Leaving one group as normal control, the other two groups were given high cholesterol diet to produce hyperlipidemia. Of the two hyperlipidemic groups, one group was treated with CoQ10 orally for 30 days. Blood samples were drawn for lipid biochemistry, 24 hours after administration of the last dose. The means of serum analysis were calculated and compared using SPSS
version 20.
Results: Serum LDL-cholesterol (LDL-C) was reduced in the group taking CoQ10 as compared to the group with no CoQ10 treatment. The p value was significant for LDL-C in treatment group, (p<0.0001).
Conclusion: It is concluded that Coenzyme Q10 plays a vital role in hyperlipidemic rabbits in reducing serum LDL cholesterol levels.