Effect of Cinnamon Bark on Streptozotocin induced Diabetic Male Mice

Authors

  • Nurain Baig Mughal, Maria Sarfaraz, Amena Rahim

Keywords:

Diabetes mellitus, Cinnamon, Blood glucose Random (BGR) and Glycosylated hemoglobin (HbA1c).

Abstract

Objective: To determine the effect of cinnamon bark on glucose metabolism in streptozotocin induced diabetic mice.
Study Design: Interventional experimental study.
Place and Duration of Study: This study was carried out in the animal house of National Institute of Health, Islamabad in collaboration with Department of Biochemistry, Islamic International Medical College from 7 November 2013 till 21 January 2014.
Materials and Methods: Fifty albino Balb/C male mice were included in study. Among them, ten mice were used for cardiac puncture for baseline biochemical analysis. While in rest of the forty mice, Type 2 diabetes was induced by intraperitoneal administration of low dose (40 mg/kg) streptozotocin (streptozotocin) injections for four consecutive days. Diabetes induction was confirmed on day 21. Two groups with twenty mice each were made. Group I was control group that was left untreated while group II received cinnamon bark diet at a dose of 5mg/day for 8 weeks.
Results: At baseline the mean BGR was 135.9±29.67 mg/dl and day 21; BGR of 336.85±46.4 mg/dl. In the experimental group the mean BGR after 08 weeks of cinnamon therapy was 184.1±24.56 mg/dl; The BGR significantly decreased after 08 weeks of cinnamon therapy as compared to Day 21 BGR; p=0.00. The mean BGR at 08 weeks was significantly decreased between the control and experimental groups; p= 0.000. At baseline the HbA1c ranged from 5.5 to 6.2 % with a mean of 5.93±0.20. In the Control group after 08 weeks the mean HbA1c was 11.27±1.28%. While in the experimental group the mean HbA1c after 08 weeks of cinnamon therapy was 7.7±0.68%. The mean HbA1c at 08 weeks was significantly decreased between the control and experimental groups; p= 0.000.
Conclusion: Cinnamon therapy was effective in improving BGR and HbA1c levels in a diabetes type 2 induced male mice.

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Published

2014-12-01

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