Loud Noise; Wound Angiogenic Stimulator or Inhibitor?
Keywords:
Angiogenesis, Noise, Skin Wound, Stimulator, Inhibitor.Abstract
Objective : To observe how loud noise affects the growth of new blood vessels in rat skin wounds.
Study Design :QUASI experimental study.
Place and Duration of Study: The study was conducted at National Institute of Health Islamabad from 28 June 2017 to 28 February 2018.
Materials and Methods: Thirty male Sprague Dawley rats were split into control and experimental groups by convenient sampling, with 15 animals belonging to each leading group. On the dorsum of each rat, a 2 cm incision was created. While experimental subgroups endured 4h/d intermittent noise exposure of 85-95db five days a week for two consecutive weeks, control subgroup rats were left to heal with routine background noise
exposure. On days 3, 7, and 14, five rats from each group were slaughtered. Wounds were excised, repaired, and prepared for H&E stain before being able to see and count the freshly grown blood vessels.
Results: Although difference in mean number of newly formed blood vessels among both control and experimental group was found with more numbers in control group but it was not statistically significant.
Conclusion: Intermittent noise exposure has tendency to impair the process of angiogenesis thus delaying wound healing.
